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Intemporel Jeunesse Botox Effect Gel

Intemporel Jeunesse Botox Effect Gel
Intemporel Jeunesse Botox Effect Gel Intemporel Jeunesse Botox Effect Gel
Brand: Vision Labs Beauty
Product Code: Intemporel Jeunesse Botox Gel 50g
Availability: In Stock
Price: R1,400.00
   - OR -   

Goodbye wrinkles, goodbye glycation

Carnosine and Powerful Antioxidants Prevent Glycation Intemporel Jeunesse Botox Effect Gel is a liposomal preparation combining carnosine, an antioxidants and anti-glycation substance with 2 powerful oil-soluble antioxidants (silymarin and tocopherol).

Glycation is a slow naturally-occurring process which affects the structure and the activity of proteins In the skin, it results in the stiffening of the dermis proteins (collagen and elastin), leading to a loss of elasticity and leads to premature aging. Oxidative stress factors and notably lipid peroxidation accelerate the glycation process.  Intemporel Jeunesse Botox Effect Gel is able to inhibit lipid peroxidation and so, prevents and slows down this deleterious process.

In a clinical study, of the active used in Intemporel Jeunesse Botox Effect Gel results was shown to:

• increase skin firmness, smoothness and hydration
• reduce the depth of wrinkles by 27 % in the crow’s feet area and by 24 % on the forehead after 1 month of treatment. Thus, Intemporel Jeunesse Botox Effect Gel can delay the glycation process and prevent oxidative aging. 
• Maintains skin elasticity prevents glycation
• Reduces wrinkles and lines
• Increases skin firmness
• Protects skin cells from oxidative aging 

Younger-Looking Skin A gel containing 2 % Intemporel Jeunesse Botox Effect Gel was applied twice daily for 28 days to the inner side of the forearm of 20 women aged from 38 to 65.
Biomechanical properties of the skin were evaluated by determining the skin firmness, hydration and smoothness using respectively a cutometer, a corneometer and the PRIMOS system.
Results showed that Intemporel Jeunesse Botox Effect Gel improved all parameters
after 28 days of treatment

Anti-wrinkle for face, décolleté and eye contour • Protective • Advanced anti-aging and anti-glycation systems.
INCI Declaration of Intemporel Jeunesse Botox Effect Gel:
Aqua, Aloe Barbadensis, Simondsia Chinensis, Lavindula Augustifolia, Linolenic Acid, Lecithin (and) Carnosine (and) Tocopherol (and) Silybum Marianum Fruit Extract (and) Glycerin (and) Ethanol, Acrylates, Beheneth-25 Methyacrylate Copolymer, Methylparaben.

Glycation, a Naturally-Occurring Process Glycation (also called Maillard or «browning» reaction) is  a slow process where reducing sugar molecules react with free amino groups of proteins leading to the formation of irreversible cross-linked molecules called AGE (advanced glycation end-products).
This process occurs naturally in most foods during heating and also, but more slowly, in living organisms at body temperature.

Glycation is a Major Contributor to Aging Glycation is deleterious to proteins as it leads to the detrimental and irreversible of their structure and activity. In skin, glycation results in the formation of rigid bridges between structural proteins such as collagen and elastin:

• making the dermis proteins stiffer and more brittle
• affecting their interactions with other cells

This results in:

• a lossof elasticity and suppleness of the skin
• the appearance of wrinkles
• the yellowing of the skin.

Oxidative Stress Promotes the Glycation Process Several factors promote the glycation process:
• high glucose levels
• aging (notably after 35)
• oxidative stress such as UV-induced lipid peroxidation which leads to the formation of malondialdehyde, a reactive compound. In their turn, the AGE formed bind to oblasts to release free radicals and reactive oxygen species (ROS), leading to a vicious circle.

Carnosine, the Anti-Glycation Factor Carnosine, a dipeptide which occurs naturally in our body, is well-known for its anti-glycation activity.
• Carnosine inhibits the cross-linking of proteins induced by reducing sugars and reactive aldehydes such as malondialdehyde.
• As a glycation target, carnosine «competes» with the skin proteins and therefore, protects collagen and elastin  In contrast to AGE, the resulting glycated carnosine is not deleterious and not toxic.

Powerful Antioxidants Reinforce Carnosine’s Effect
• Silymarin is the major active substance of milk thistle,  a flowering plant of the daisy family.  This polyphenol supports physiological antioxidants and radical scavengers such as glutathione and superoxide dismutase and is also able to capture and neutralize free radicals. It inhibits lipid peroxidation and inflammation as well as the release of histamine.
• Tocopherol is naturally present in the skin being the major lipid-soluble antioxidant. Located in cellular  membranes, it protects skin lipids against peroxidation and maintains the barrier function.
• The liposomal form increases the bioavailability of all compounds thanks to the small size of the liposomes and their high af to the stratum corneum. This results in an enhanced and long-lasting activity.

Malondialdehyde Promotes the Glycation Process Malondialdehyde (MDA) is a reactive aldehydic molecule which accelerates the glycation process. It  results from the degradation of polyunsaturated fatty acids by ROS which are mostly generated by UVA. Malondialdehyde  is thus a marker for oxidative stress. Malondialdehyde damages proteins by oxidizing them and by modifying their structure and function leading to the formation of AGE.

Antioxidant and Anti-Glycation Effects of Intemporel Jeunesse Botox Effect Gel Different concentrations of Intemporel Jeunesse Botox Effect Gel were added to borage oil that was encapsulated in a nano-emulsion. This oil is rich in polyunsaturated fatty acids and thus sensitive to UV . Then, the nano-emulsions were radiated with UVA light (2 hours at 500 Watt) leading to the formation of lipid peroxides. The concentration of lipid peroxides was measured using the thiobarbituric acid assay. This technique is based on the transformation of lipid peroxides into malondialdehyde which forms a red complex with thiobarbituric acid. The absorbance of this complex is measured at 532 nm using a spectrophotometer.
Results showed that Intemporel Jeunesse Botox Effect Gel clearly inhibited the lipid peroxidation and the formation of MDA in a dose-dependent manner indicating an antioxidant and anti-glycation effect.

All information is based on the active complex used in Intemporel Jeunesse Botox Effect Gel




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